Sugi Predict

Sugi Predict / Compounds / SCHEMBL8043283

SCHEMBL8043283

SCHEMBL8043283

C=C(/N=C/c1cc(F)ccc1OC)O[Si](C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 1/20 0.38
▸ SLC9A1 P19634 2/20 0.38
▸ AR P10275 1/20 0.36
▸ NFE2L2 Q16236 2/20 0.36
▸ MPO P05164 1/20 0.35
▸ MAPT P10636 5/20 0.35
▸ LMNA P02545 3/20 0.34
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ RELA Q04206 1/20 0.34
▸ HTT P42858 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ AMY1A P0DUB6 1/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL279191 0.88 LMNA (0.43) NFE2L2MAPTLMNASMN1; SMN2KDM4E
SCHEMBL275415 0.86 MAPT (0.38) MAPTRAB9AMEN1KMT2AL3MBTL1
SCHEMBL279428 0.86 MAPT (0.38) MAPTRAB9AMEN1KMT2AL3MBTL1
SCHEMBL279179 0.86 LMNA (0.44) MAPTLMNAHTTMAPK1ALDH1A1
SCHEMBL275677 0.86 LMNA (0.44) MAPTLMNAHTTMAPK1ALDH1A1
SCHEMBL7840021 0.85 NFE2L2 (0.36) SLC9A1NFE2L2MAPTRAB9A
SCHEMBL7841968 0.84 KMT2A (0.42) ERN1MAPTKDM4ERAB9AMEN1
SCHEMBL7737189 0.83 MAPT (0.33) SLC9A1MPOMAPTRAB9A
SCHEMBL274398 0.83 PDE4D (0.36) —
SCHEMBL279473 0.83 PDE4D (0.36) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7495007-B2 Spiroindolinone derivatives HOFFMANN-LA ROCHE INC. (US) 2009-02-24 — — US disclosed
US-7495007-B2 Spiroindolinone derivatives HOFFMANN-LA ROCHE INC. (US) 2009-02-24 — — US disclosed
US-20080188506-A1 SPIROINDOLINONE DERIVATIVES DING QINGJIE 2008-08-07 — — US disclosed
US-20080009486-A1 SPIROINDOLINONE DERIVATIVES HOFFMANN-LA ROCHE INC. 2008-01-10 — — US disclosed
US-20080009486-A1 SPIROINDOLINONE DERIVATIVES HOFFMANN-LA ROCHE INC. 2008-01-10 — — US disclosed
WO-2007104664-A1 SPIROINDOLINONE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-09-20 — — WO disclosed
US-20070213341-A1 Spiroindolinone derivatives CHEN LI 2007-09-13 — — US disclosed
US-20070213341-A1 Spiroindolinone derivatives CHEN LI 2007-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080009486-A1 SPIROINDOLINONE DERIVATIVES RB1, PKD1, KRAS ERN1 974/4885SLC9A1 1811/4885AR 19/4885
US-20080188506-A1 SPIROINDOLINONE DERIVATIVES MKI67, MCL1, BAD ERN1 2204/4885SLC9A1 1976/4885AR 49/4885
US-20070213341-A1 Spiroindolinone derivatives MKI67, PKD1, RCC2 ERN1 2299/4885SLC9A1 1580/4885AR 41/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.