Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.45 |
| ▸ | PDE6C | P51160 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE8A | O60658 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051166 | 0.87 | PDE5A (0.45) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL8044800 | 0.85 | PDE5A (0.44) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL8041296 | 0.85 | PDE5A (0.48) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL4125332 | 0.80 | PDE5A (0.46) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL4136563 | 0.79 | PDE5A (0.43) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL4142307 | 0.78 | PDE5A (0.47) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL4902005 | 0.77 | PDE5A (0.56) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL8043859 | 0.75 | KDM4E (0.36) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL4901618 | 0.75 | PDE5A (0.41) | PDE5APDE6CMTORTERTPDE1A | |
| SCHEMBL8048797 | 0.75 | PDE9A (0.38) | PDE5APDE6CPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |