Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043859 | 0.90 | KDM4E (0.36) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8034133 | 0.86 | KDM4E (0.36) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8051166 | 0.84 | PDE5A (0.45) | PDE9APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4143162 | 0.82 | GAA (0.42) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL4123024 | 0.79 | ALDH1A1 (0.36) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL4131950 | 0.77 | GAA (0.41) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL4901385 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8044800 | 0.77 | PDE5A (0.44) | PDE9APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4134627 | 0.76 | MAPT (0.34) | KDM4EALDH1A1MAPTNPSR1POLB | |
| SCHEMBL8042659 | 0.76 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |