Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043550 | 0.91 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19L3MBTL1RXFP1 | |
| SCHEMBL8043558 | 0.86 | TRPV1 (0.46) | CYP1A2LMNATDP1ALDH1A1KDM4E | |
| SCHEMBL8032107 | 0.84 | HIF1A (0.45) | LMNAKDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL8045505 | 0.80 | HIF1A (0.45) | LMNAKDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL8043588 | 0.80 | HIF1A (0.43) | LMNAALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL8045497 | 0.80 | TRPV1 (0.44) | CYP1A2LMNAKDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL8042356 | 0.79 | HIF1A (0.50) | L3MBTL1LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL8041606 | 0.78 | HIF1A (0.51) | LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8043531 | 0.78 | METAP1 (0.49) | LMNAMAPTKDM4ENPC1NFKB1 | |
| SCHEMBL8049621 | 0.78 | HIF1A (0.44) | LMNAKDM4ESMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |