Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051092 | 0.86 | ATM (0.47) | ATMSMN1; SMN2TERTHTTMEN1 | |
| SCHEMBL8043099 | 0.82 | TSHR (0.57) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8046642 | 0.82 | ALDH1A1 (0.36) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8716255 | 0.81 | TP53 (0.43) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8042649 | 0.80 | ALDH1A1 (0.36) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8044131 | 0.80 | RPA1 (0.44) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8043752 | 0.79 | KDM4E (0.48) | SMN1; SMN2HTTMEN1KMT2ATSHR | |
| SCHEMBL8047373 | 0.78 | SMN1; SMN2 (0.47) | ATMSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL8042116 | 0.77 | SMN1; SMN2 (0.41) | ATMSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL8051302 | 0.77 | ATM (0.48) | ATMSMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |