Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050065 | 0.88 | KDM4E (0.52) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8042708 | 0.80 | ALDH1A1 (0.52) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8047964 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8044969 | 0.80 | ALDH1A1 (0.45) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8043099 | 0.79 | TSHR (0.57) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8043571 | 0.79 | ATM (0.43) | ALDH1A1HPGDSMN1; SMN2TSHRMEN1 | |
| SCHEMBL8046642 | 0.79 | ALDH1A1 (0.36) | KDM4EALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8034048 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 | |
| SCHEMBL8716255 | 0.78 | TP53 (0.43) | KDM4EALDH1A1HPGDCYP1A2RAB9A | |
| SCHEMBL8044821 | 0.78 | ALDH1A1 (0.47) | KDM4EALDH1A1CYP2C9HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |