Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042199 | 0.89 | ALPG (0.46) | MAPTKMT2AKDM4EMEN1JAK2 | |
| SCHEMBL8050309 | 0.87 | ALDH1A1 (0.44) | MAPTKMT2AKDM4EMEN1JAK2 | |
| SCHEMBL8045447 | 0.86 | POLA1 (0.41) | MAPTKMT2AKDM4EMEN1JAK2 | |
| SCHEMBL8033875 | 0.86 | MAPT (0.45) | MAPTKMT2AKDM4EMEN1JAK2 | |
| SCHEMBL8033784 | 0.85 | ALPG (0.42) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8033695 | 0.83 | ALPG (0.44) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8044539 | 0.83 | ALPG (0.44) | MAPTKMT2AKDM4EMEN1ATM | |
| SCHEMBL8033699 | 0.82 | KMT2A (0.55) | MAPTKMT2AKDM4EMEN1JAK2 | |
| SCHEMBL8042393 | 0.81 | ALPG (0.40) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8032437 | 0.81 | ALPG (0.42) | MAPTKMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |