Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282614 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2ATDP1MEN1 | |
| SCHEMBL22917100 | 0.82 | LTA4H (0.57) | SMN1; SMN2TSHRPARP10 | |
| SCHEMBL12643206 | 0.79 | MMP13 (0.50) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL17679407 | 0.79 | MMP13 (0.50) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL19412563 | 0.79 | MMP13 (0.50) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL6034956 | 0.78 | ALDH1A1 (0.74) | MMP13ALDH1A1MAPTKMT2AMAPK14 | |
| SCHEMBL95343 | 0.78 | TEAD4 (0.74) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL83814 | 0.78 | TEAD4 (0.74) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL83863 | 0.78 | TEAD4 (0.74) | MMP13TEAD4ALDH1A1MAPTKMT2A | |
| SCHEMBL16442727 | 0.78 | MMP13 (0.49) | MMP13TEAD4ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062676-A2 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |