Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.58 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584085 | 0.93 | EPHX1 (0.46) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| SCHEMBL27690359 | 0.85 | EPHX1 (0.39) | TRPM8TRPA1EPHX1 | |
| Menthol SCHEMBL8644395 | 0.84 | TRPM8 (0.64) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL15914500 | 0.84 | TRPM8 (0.68) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL15646159 | 0.82 | TRPM8 (0.70) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL17459804 | 0.82 | TRPM8 (0.60) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL1665362 | 0.81 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL2671170 | 0.81 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL16879064 | 0.81 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1TRPV1 | |
| Menthol SCHEMBL1664554 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121315-A | MIXTURE CONTAINING MENTHYL SUCCINATE COOLANT | WARNER-LAMBERT COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1998011867-A1 | ORAL COMPOSITIONS CONTAINING A ZINC COMPOUND | WARNER-LAMBERT COMPANY (US) | 1998-03-26 | — | — | WO | disclosed |