Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.72 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.72 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL13730660 | 0.97 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Levomenthol SCHEMBL2052644 | 0.93 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2052642 | 0.93 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL16879064 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2671170 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27888021 | 0.89 | TRPM8 (0.62) | TRPM8TRPA1EPHX1ALDH1A1 | |
| Menthol SCHEMBL1664554 | 0.89 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL28812835 | 0.88 | TRPM8 (0.70) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27647822 | 0.88 | TRPM8 (0.70) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27544760 | 0.88 | TRPM8 (0.70) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109661180-A | Composition and production and preparation method thereof for sports achievement | 西雅图咖米公司 | 2019-04-19 | — | — | CN | claimed |
| CN-109640703-A | Composition and production and preparation method thereof for mental alertness | 西雅图咖米公司 | 2019-04-16 | — | — | CN | claimed |
| CN-109640704-A | Composition and production and preparation method thereof for postexercise recovery | 西雅图咖米公司 | 2019-04-16 | — | — | CN | claimed |
| CN-109640705-A | Mineral composition and its preparation and application | 西雅图咖米公司 | 2019-04-16 | — | — | CN | claimed |
| CN-109561727-A | Health control composition and its preparation and application | 西雅图咖米公司 | 2019-04-02 | — | — | CN | claimed |
| CN-107382931-A | A kind of menthol flavor precursor compound and preparation method and application | 云南中烟工业有限责任公司 | 2017-11-24 | — | — | CN | claimed |
| US-12601929-B2 | Contact lens | COOPERVISION INTERNATIONAL LIMITED (GB) | 2026-04-14 | — | — | US | disclosed |
| EP-4388349-B1 | CONTACT LENS | COOPERVISION INT LTD (GB) | 2025-03-12 | — | — | EP | disclosed |
| US-12153288-B2 | Contact lens | COOPERVISION INTERNATIONAL LIMITED (GB) | 2024-11-26 | — | — | US | disclosed |
| CN-115558126-B | Dynamically crosslinked hyaluronic acid hydrogel | 海诺生物科技有限公司 | 2024-11-15 | — | — | CN | disclosed |
| US-20240264469-A1 | CONTACT LENS | COOPERVISION INTERNATIONAL LIMITED (GB) | 2024-08-08 | — | — | US | disclosed |
| EP-4388349-A1 | CONTACT LENS | CooperVision International Limited (GB) | 2024-06-26 | — | — | EP | disclosed |
| US-20230350228-A1 | CONTACT LENS | COOPERVISION INTERNATIONAL LIMITED (GB) | 2023-11-02 | — | — | US | disclosed |
| US-20060110442-A1 | Coated sherical seamless filled capsules | SYMRISE GMBH & CO. KG (DE) | 2006-05-25 | — | — | US | disclosed |
| WO-2005077521-A1 | COATED SHERICAL SEAMLESS FILLED CAPSULES | SYMRISE GMBH & CO. KG (DE) | 2005-08-25 | — | — | WO | disclosed |
| US-6506368-B2 | Encapsulating a mixture of a lipophilic core material and an oil-soluble dye, wherein said dye is D&C Green No. 6 or guaizulene or mixture of two dyes | HAARMANN & REIMBER GMBH (DE) | 2003-01-14 | — | — | US | disclosed |
| US-20020159957-A1 | Process for producing blue microcapsules | SYMRISE AG (DE) | 2002-10-31 | — | — | US | disclosed |
| US-4178458-A | COOLING ACTION ON SKIN | PHILIP MORRIS, INC. (US) | 1979-12-11 | — | — | US | disclosed |
| US-4141906-A | 2,2-DIMETHYL-3-HYDROXY-3-(3',4'-METHYLENEDIOXYPHENYL-) PROPIONIC ACID OR ITS ETHYL ESTER | PHILIP MORRIS INCORPORATED (US) | 1979-02-27 | — | — | US | disclosed |
| US-4036237-A | Smoking composition | PHILIP MORRIS INCORPORATED (US) | 1977-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12601929-B2 | Contact lens | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885TRPA1 4/4885EPHX1 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.