Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044461 | 0.89 | SMN1; SMN2 (0.40) | ALDH1A1HSD17B10HPGDGAAMAPT | |
| SCHEMBL8044470 | 0.86 | MAPT (0.33) | ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL8047154 | 0.86 | MAPT (0.36) | ALDH1A1GAAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL8041916 | 0.85 | MAPT (0.35) | ALDH1A1HSD17B10MAPTSMN1; SMN2KDM4E | |
| SCHEMBL8047155 | 0.83 | MAPT (0.37) | ALDH1A1HSD17B10GAAMAPTLMNA | |
| SCHEMBL8043964 | 0.82 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL8032914 | 0.80 | MAPT (0.35) | ALDH1A1HSD17B10HPGDGAAMAPT | |
| SCHEMBL8043579 | 0.80 | MAPT (0.35) | ALDH1A1MAPTPOLB | |
| SCHEMBL8051739 | 0.79 | ALDH1A1 (0.37) | ALDH1A1HSD17B10HPGDGAAMAPT | |
| SCHEMBL8046194 | 0.79 | MAPT (0.34) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |