Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043686 | 0.89 | ALDH1A1 (0.37) | SMN1; SMN2POLBHSD17B10ALDH1A1MEN1 | |
| SCHEMBL8047155 | 0.85 | MAPT (0.37) | SMN1; SMN2POLBHSD17B10ALDH1A1MEN1 | |
| SCHEMBL8046194 | 0.85 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL8034362 | 0.83 | F2 (0.39) | POLBALDH1A1MAPT | |
| SCHEMBL8047154 | 0.83 | MAPT (0.36) | SMN1; SMN2POLBALDH1A1KMT2AMAPT | |
| SCHEMBL8041916 | 0.82 | MAPT (0.35) | SMN1; SMN2HSD17B10ALDH1A1MAPTCYP2C9 | |
| SCHEMBL8032914 | 0.82 | MAPT (0.35) | SMN1; SMN2POLBHSD17B10ALDH1A1MEN1 | |
| SCHEMBL8043579 | 0.81 | MAPT (0.35) | POLBALDH1A1MAPT | |
| SCHEMBL8043964 | 0.79 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL8043918 | 0.79 | MAPT (0.45) | POLBHSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |