Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042199 | 0.86 | ALPG (0.46) | CYP3A4NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL8033699 | 0.85 | KMT2A (0.55) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8051559 | 0.85 | KDM4E (0.45) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8043944 | 0.84 | MAPT (0.54) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8049971 | 0.81 | RPA1 (0.49) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL8042609 | 0.81 | SMN1; SMN2 (0.42) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL8042984 | 0.81 | TSHR (0.50) | TSHRCYP3A4CYP2C19ALDH1A1MEN1 | |
| SCHEMBL8044735 | 0.81 | SMN1; SMN2 (0.40) | TP53NPC1RAB9ANPSR1HTT | |
| SCHEMBL8042974 | 0.80 | KDM4E (0.52) | TP53CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL8050930 | 0.80 | NFKB1 (0.45) | TP53NPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |