Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050060 | 0.86 | HTT (0.46) | SMN1; SMN2KDM4ELMNAHSD17B10MAPT | |
| SCHEMBL8044446 | 0.86 | KMT2A (0.41) | SMN1; SMN2KDM4ELMNAILKHSD17B10 | |
| SCHEMBL8045077 | 0.84 | PDK1 (0.46) | SMN1; SMN2LMNAPTPN1NPC1TP53 | |
| SCHEMBL8043741 | 0.81 | TP53 (0.51) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8049971 | 0.81 | RPA1 (0.49) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042609 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042984 | 0.81 | TSHR (0.50) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042974 | 0.80 | KDM4E (0.52) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8050930 | 0.79 | NFKB1 (0.45) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042199 | 0.78 | ALPG (0.46) | KDM4ELMNANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |