Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710810 | 0.91 | MAPT (0.50) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8033875 | 0.86 | MAPT (0.45) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8051559 | 0.85 | KDM4E (0.45) | MAPTHTTLMNAALDH1A1MEN1 | |
| SCHEMBL8033699 | 0.84 | KMT2A (0.55) | MAPTMAPK1HTTLMNAALDH1A1 | |
| SCHEMBL8043741 | 0.84 | TP53 (0.51) | HTTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8047056 | 0.82 | TSHR (0.48) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8048212 | 0.82 | PDK1 (0.48) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8051667 | 0.82 | PDK1 (0.48) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8045077 | 0.82 | PDK1 (0.46) | MAPTMAPK1HTTLMNAPDK1 | |
| SCHEMBL8044720 | 0.81 | PDK1 (0.45) | MAPTMAPK1HTTLMNAPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |