Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162849 | 0.77 | BTK (0.44) | PDE2APDE10ADHODHELANEKDM4E | |
| SCHEMBL2752958 | 0.76 | NUDT1 (0.39) | MKNK2PDPK1P2RX7GAANPC1 | |
| SCHEMBL1450105 | 0.76 | MKNK1 (0.45) | MKNK1MKNK2TDO2VHLPDE2A | |
| SCHEMBL5148218 | 0.76 | KDM4E (0.54) | MKNK1MKNK2TDO2VHLPDE10A | |
| SCHEMBL31469002 | 0.75 | MKNK1 (0.52) | MKNK1MKNK2TDO2VHLPDE2A | |
| SCHEMBL3421959 | 0.75 | MKNK1 (0.52) | MKNK1MKNK2TDO2VHLPDE2A | |
| SCHEMBL2156047 | 0.73 | MKNK1 (0.53) | MKNK1MKNK2TDO2VHLPDE2A | |
| SCHEMBL2751007 | 0.73 | CDK2 (0.38) | PDE10ANPC1 | |
| SCHEMBL1450328 | 0.72 | KDM4E (0.36) | BLMKDM4ELMNACYP1A2POLB | |
| SCHEMBL4976600 | 0.72 | ALDH1A1 (0.44) | BLMKDM4ELMNACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |