Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 10/20 | 0.42 |
| ▸ | CA2 | P00918 | 10/20 | 0.42 |
| ▸ | CA9 | Q16790 | 8/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 6/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050828 | 0.90 | ALDH1A1 (0.48) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8046892 | 0.89 | EP300 (0.43) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8051515 | 0.88 | HPGD (0.49) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL8042315 | 0.87 | KMT2A (0.46) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8042810 | 0.85 | ALDH1A1 (0.43) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8050355 | 0.85 | MAPT (0.44) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL8048023 | 0.85 | ALDH1A1 (0.42) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8048593 | 0.84 | CYP1A2 (0.52) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL8043280 | 0.84 | MAPT (0.41) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8716341 | 0.84 | HPGD (0.45) | KMT2AMEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |