Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048593 | 0.92 | CYP1A2 (0.52) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8050828 | 0.91 | ALDH1A1 (0.48) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8051515 | 0.89 | HPGD (0.49) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8042315 | 0.89 | KMT2A (0.46) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8042810 | 0.87 | ALDH1A1 (0.43) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8048023 | 0.87 | ALDH1A1 (0.42) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8043280 | 0.86 | MAPT (0.41) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8043891 | 0.85 | PTGS2 (0.46) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL8716341 | 0.85 | HPGD (0.45) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8042692 | 0.84 | POLB (0.46) | MAPTKMT2AMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |