SCHEMBL8048593

SCHEMBL8048593

COc1ccc(-n2nnnc2Sc2ncc(NC(=O)c3ccccc3)s2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
MAPT P10636 3/20 0.47
MAPK1 P28482 2/20 0.47
TSHR P16473 2/20 0.47
LMNA P02545 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 5/20 0.47
CSNK2A2 P19784 1/20 0.46
CSNK2A1 P68400 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NTRK1 P04629 1/20 0.44
NTRK2 Q16620 1/20 0.44
HPGD P15428 1/20 0.44
HK1 P19367 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8050355 0.92 MAPT (0.44) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8050828 0.90 ALDH1A1 (0.48) MAPTMAPK1TSHRLMNAKDM4E
SCHEMBL8051515 0.89 HPGD (0.49) MAPTMAPK1TSHRLMNAALDH1A1
SCHEMBL8042810 0.88 ALDH1A1 (0.43) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8048023 0.88 ALDH1A1 (0.42) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8042315 0.88 KMT2A (0.46) MAPTMAPK1TSHRLMNAKDM4E
SCHEMBL8043280 0.87 MAPT (0.41) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8043891 0.84 PTGS2 (0.46) MAPTMAPK1LMNAALDH1A1SMN1; SMN2
SCHEMBL8716341 0.84 HPGD (0.45) MAPTMAPK1TSHRLMNAALDH1A1
SCHEMBL8042692 0.83 POLB (0.46) CYP3A4MAPTMAPK1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed
WO-1998027092-A1 THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION SUGEN, INC. (US) 1998-06-25 WO disclosed