Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045484 | 0.85 | HDAC6 (0.57) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8033853 | 0.80 | NPC1 (0.44) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8032385 | 0.80 | ALDH1A1 (0.48) | RAB9ASMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL8032616 | 0.80 | SMN1; SMN2 (0.54) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8052179 | 0.79 | RAB9A (0.48) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8048704 | 0.79 | NPSR1 (0.45) | RAB9ASMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL8044457 | 0.79 | HDAC6 (0.57) | KDM4ERAB9AALDH1A1NPC1HPGD | |
| SCHEMBL8049839 | 0.79 | KMT2A (0.52) | RAB9ASMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL8050726 | 0.78 | KDM4E (0.44) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8050097 | 0.78 | NPC1 (0.58) | RAB9ASMN1; SMN2ALDH1A1NPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |