Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043923 | 0.85 | KDM4E (0.47) | HDAC6NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8032385 | 0.84 | ALDH1A1 (0.48) | HDAC6NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8032616 | 0.84 | SMN1; SMN2 (0.54) | HDAC6NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8050097 | 0.83 | NPC1 (0.58) | HDAC6NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8033853 | 0.82 | NPC1 (0.44) | HDAC6NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8045973 | 0.82 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL8041902 | 0.81 | MAPT (0.46) | HDAC6CSNK2A2CSNK2A1NPC1RAB9A | |
| SCHEMBL8043290 | 0.81 | CCNE1 (0.47) | HDAC6NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8052179 | 0.81 | RAB9A (0.48) | HDAC6NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8048704 | 0.81 | NPSR1 (0.45) | HDAC6NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |