Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042618 | 0.88 | ALDH1A1 (0.50) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8043628 | 0.87 | HPGD (0.59) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8044035 | 0.83 | HSD17B10 (0.51) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8048077 | 0.83 | MAPT (0.51) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8038022 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8044052 | 0.81 | MAPK1 (0.49) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8042757 | 0.81 | CYP1A2 (0.53) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8046503 | 0.81 | HSD17B10 (0.55) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL8032357 | 0.80 | AKR1B1 (0.44) | HPGDALDH1A1MAPK1TSHRMAPT | |
| SCHEMBL8033602 | 0.80 | CYP1A2 (0.48) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |