Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044486 | 0.87 | SMN1; SMN2 (0.54) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8044052 | 0.84 | MAPK1 (0.49) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8043621 | 0.84 | GLA (0.51) | HPGDMAPK1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8050099 | 0.83 | NFKB1 (0.44) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8033602 | 0.83 | CYP1A2 (0.48) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8048253 | 0.82 | ALDH1A1 (0.52) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8044035 | 0.81 | HSD17B10 (0.51) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8051893 | 0.81 | HDAC6 (0.39) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8042618 | 0.81 | ALDH1A1 (0.50) | HPGDMAPK1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL8043241 | 0.81 | FBP1 (0.50) | HPGDMAPK1HSD17B10SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |