SCHEMBL8044559

SCHEMBL8044559

O=C(O)c1cnc(Sc2nnc(-c3ccccc3)s2)s1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.54
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
ALDH1A1 P00352 4/20 0.44
MAPT P10636 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
PKM P14618 2/20 0.43
HDAC1 Q13547 2/20 0.43
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
RXRA P19793 1/20 0.40
RXRB P28702 1/20 0.40
RXRG P48443 1/20 0.40
CYP1A2 P05177 1/20 0.40
GSK3B P49841 1/20 0.40
ELANE P08246 2/20 0.39
HCAR2 Q8TDS4 1/20 0.38
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8050726 0.82 KDM4E (0.44) NPC1RAB9AALDH1A1MAPTSMN1; SMN2
SCHEMBL8052110 0.80 ALDH1A1 (0.45) HDAC6NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL8032493 0.79 RAB9A (0.44) NPC1RAB9AALDH1A1SMN1; SMN2MEN1
SCHEMBL6497988 0.79 HDAC6 (0.49) HDAC6NPC1RAB9AALDH1A1MAPT
SCHEMBL8050254 0.78 HDAC6 (0.45) HDAC6NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL8048020 0.78 HCAR2 (0.56) NPC1RAB9AALDH1A1MAPTSMN1; SMN2
SCHEMBL8045484 0.77 HDAC6 (0.57) HDAC6NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL8050918 0.77 MAPK8 (0.55) NPC1RAB9AALDH1A1MAPTPKM
SCHEMBL8042976 0.76 HDAC6 (0.43) HDAC6NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL8042773 0.76 MAPK8 (0.61) HDAC6NPC1RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed