Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045879 | 0.89 | ALDH1A1 (0.60) | MEN1KMT2AHPGDPOLBPDK1 | |
| SCHEMBL8033820 | 0.88 | ALDH1A1 (0.49) | RECQLMEN1KMT2AHPGDPOLB | |
| SCHEMBL8042611 | 0.87 | PDK1 (0.53) | MEN1KMT2AHPGDPDK1ALDH1A1 | |
| SCHEMBL8033645 | 0.86 | PDK1 (0.51) | MEN1KMT2AHPGDPOLBPDK1 | |
| SCHEMBL8045309 | 0.85 | ALDH1A1 (0.51) | MEN1KMT2AHPGDPOLBPDK1 | |
| SCHEMBL8044622 | 0.85 | CA2 (0.53) | MEN1KMT2AHPGDPOLBPDK1 | |
| SCHEMBL8042108 | 0.85 | PDK1 (0.50) | MEN1KMT2AHPGDPDK1ALDH1A1 | |
| SCHEMBL8049105 | 0.85 | PDK1 (0.50) | MEN1KMT2AHPGDPDK1ALDH1A1 | |
| SCHEMBL8049955 | 0.85 | PDK1 (0.50) | MEN1KMT2AHPGDPOLBPDK1 | |
| SCHEMBL8044411 | 0.83 | KMT2A (0.55) | MEN1KMT2AHPGDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |