Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | ESR1 | P03372 | 4/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834650 | 0.81 | HDAC1 (0.71) | HDAC8HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL8563996 | 0.76 | ESR1 (0.53) | ESR1ESR2CYP3A4MEN1ALDH1A1 | |
| SCHEMBL10579894 | 0.76 | ESR1 (0.53) | ESR1ESR2CYP3A4MEN1ALDH1A1 | |
| SCHEMBL6138433 | 0.75 | HDAC1 (0.57) | HDAC8HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL7832947 | 0.73 | HDAC1 (0.48) | HDAC8HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL7841213 | 0.71 | HDAC1 (0.46) | HDAC8HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL14917995 | 0.71 | TBXAS1 (0.40) | CYP1A2CYP2C19ALOX5 | |
| SCHEMBL8035262 | 0.69 | HDAC1 (0.51) | HDAC8HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL28493147 | 0.69 | ESR1 (0.59) | ESR1ESR2CYP3A4MEN1ALDH1A1 | |
| SCHEMBL6138535 | 0.69 | MMP3 (0.64) | HDAC8HDAC1HDAC2HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749957-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5891916-A | ANTINEUROGEGERATIVE AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0749957-A1 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | disclosed |