Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 13/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051390 | 0.77 | GPR55 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20575147 | 0.75 | HTR7 (0.53) | GPR55NTRK1 | |
| SCHEMBL20575148 | 0.75 | HTR7 (0.53) | GPR55NTRK1 | |
| SCHEMBL1366564 | 0.73 | GPR55 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8058012 | 0.73 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1366562 | 0.73 | GPR55 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1365910 | 0.72 | NTRK1 (0.47) | GPR55NTRK1CCNT1CDK9 | |
| SCHEMBL1365913 | 0.72 | NTRK1 (0.47) | GPR55NTRK1CCNT1CDK9 | |
| SCHEMBL1367667 | 0.70 | GPR55 (0.46) | GPR55NTRK1 | |
| SCHEMBL1367669 | 0.70 | GPR55 (0.46) | GPR55NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |