Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 13/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.41 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.41 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.41 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.41 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.41 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17723376 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTGAAATP1A1 | |
| SCHEMBL8038833 | 0.83 | PDE2A (0.44) | GPR55ALDH1A1MAPTPSEN1PSEN2 | |
| SCHEMBL8038836 | 0.82 | NPC1 (0.48) | GPR55ALDH1A1MAPTPSEN1PSEN2 | |
| SCHEMBL8057713 | 0.80 | PSEN1 (0.44) | ALDH1A1MAPTPKMHPGDHTT | |
| SCHEMBL8045009 | 0.77 | PSEN1 (0.45) | GPR55PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1367667 | 0.76 | GPR55 (0.46) | GPR55ALDH1A1GAANTRK1 | |
| SCHEMBL1367669 | 0.76 | GPR55 (0.46) | GPR55ALDH1A1GAANTRK1 | |
| SCHEMBL1365910 | 0.75 | NTRK1 (0.47) | GPR55NTRK1 | |
| SCHEMBL3557473 | 0.75 | AURKA (0.52) | GPR55NTRK1 | |
| SCHEMBL20575147 | 0.75 | HTR7 (0.53) | GPR55NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |