Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062769 | 0.85 | PDGFRA (0.34) | BRAFPDGFRAACVR1BPIK3CARIPK1 | |
| SCHEMBL8062997 | 0.84 | PIK3CA (0.34) | BRAFPDGFRAACVR1BPIK3CARIPK1 | |
| SCHEMBL8062746 | 0.82 | RXRA (0.36) | ALDH1A1KDM4EHSD17B10HTTMAPT | |
| SCHEMBL8062776 | 0.81 | ALDH1A1 (0.34) | ALDH1A1KDM4EHSD17B10HTTMAPT | |
| SCHEMBL8045064 | 0.81 | CFTR (0.36) | BRAFPDGFRAACVR1BPIK3CARIPK1 | |
| SCHEMBL8060847 | 0.80 | — | — | |
| SCHEMBL8062982 | 0.80 | ALDH1A1 (0.34) | ALDH1A1KDM4EHSD17B10HTTMAPT | |
| SCHEMBL8057402 | 0.79 | ALDH1A1 (0.36) | ALDH1A1KDM4EHSD17B10HTTMAPT | |
| SCHEMBL8062745 | 0.79 | ALDH1A1 (0.34) | ALDH1A1KDM4EHSD17B10HTTMAPT | |
| SCHEMBL8056978 | 0.79 | RXRA (0.34) | ALDH1A1KDM4EHSD17B10HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |