Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 13/20 | 0.58 |
| ▸ | NOS3 | P29474 | 10/20 | 0.58 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8098153 | 0.99 | NOS2 (0.57) | NOS2NOS3ACHEHTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL8090054 | 0.73 | NOS3 (0.97) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL8106647 | 0.67 | NOS2 (0.97) | NOS2NOS3 | |
| SCHEMBL8057607 | 0.65 | NOS2 (1.00) | NOS2NOS3 | |
| SCHEMBL8057623 | 0.65 | NOS2 (0.56) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL8100105 | 0.64 | NOS2 (0.97) | NOS2NOS3 | |
| SCHEMBL8045503 | 0.64 | NOS2 (1.00) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL8107228 | 0.64 | NOS2 (0.55) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL8099873 | 0.64 | NOS2 (0.97) | NOS2NOS3 | |
| SCHEMBL8233735 | 0.64 | NOS2 (0.71) | NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027052-A1 | NOVEL COMBINATION | AstraZeneca UK Limited (GB) | 2000-08-16 | — | — | EP | claimed |
| US-6046191-A | PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS | ASTRA PHARMACEUTICALS LTD. (GB) | 2000-04-04 | — | — | US | claimed |
| WO-1999018960-A1 | NOVEL COMBINATION | ASTRAZENECA UK LIMITED (GB) | 1999-04-22 | — | — | WO | claimed |
| EP-1027052-A1 | NOVEL COMBINATION | AstraZeneca UK Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| US-6046191-A | PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS | ASTRA PHARMACEUTICALS LTD. (GB) | 2000-04-04 | — | — | US | disclosed |
| WO-1999018960-A1 | NOVEL COMBINATION | ASTRAZENECA UK LIMITED (GB) | 1999-04-22 | — | — | WO | disclosed |