SCHEMBL8057607

SCHEMBL8057607

NC1=NC(c2ccco2)Cc2ccsc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 17/20 1.00
NOS3 P29474 13/20 1.00
NOS1 P29475 1/20 0.36
GAA P10253 1/20 0.35
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8100105 0.99 NOS2 (0.97) NOS2NOS3NOS1GAAALDH1A1
Hydrochloric Acid SCHEMBL8090005 0.78 NOS2 (0.64) NOS2NOS3NOS1GAAALDH1A1
SCHEMBL8056730 0.77 NOS3 (1.00) NOS2NOS3
SCHEMBL8045546 0.75 NOS3 (1.00) NOS2NOS3ALDH1A1MAPTTDP1
Hydrochloric Acid SCHEMBL8090054 0.75 NOS3 (0.97) NOS2NOS3
SCHEMBL8045504 0.75 NOS2 (1.00) NOS2NOS3NOS1
SCHEMBL8057614 0.75 NOS3 (0.66) NOS2NOS3
Hydrochloric Acid SCHEMBL8106647 0.74 NOS2 (0.97) NOS2NOS3NOS1
Hydrochloric Acid SCHEMBL8097995 0.74 NOS3 (0.97) NOS2NOS3ALDH1A1MAPTTDP1
Hydrochloric Acid SCHEMBL8090656 0.74 NOS3 (0.64) NOS2NOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP claimed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed