Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NGFR | P08138 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315715 | 0.81 | ALDH1A1 (0.59) | NGFRCA12CA9ALDH1A1MEN1 | |
| SCHEMBL3918945 | 0.78 | KDM4E (0.56) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL7155170 | 0.77 | ALDH1A1 (0.71) | CA12CA9ALDH1A1MEN1KMT2A | |
| SCHEMBL1155981 | 0.75 | NGFR (0.53) | NGFRCA12CA9ALDH1A1MEN1 | |
| SCHEMBL28273162 | 0.73 | KDM4E (0.51) | NGFRCA12CA9ALDH1A1KDM4E | |
| SCHEMBL6614826 | 0.73 | ALDH1A1 (0.69) | NGFRCA12CA9ALDH1A1MEN1 | |
| SCHEMBL9540712 | 0.72 | SIRT1 (0.49) | NGFRSIRT1CA12CA9AR | |
| SCHEMBL31025912 | 0.71 | MEN1 (0.48) | NGFRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13684477 | 0.70 | ALDH1A1 (0.57) | NGFRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28338744 | 0.69 | KDM4E (0.48) | NGFRALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563475-B1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5846545-A | Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs | IMMUNOGEN, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5585499-A | DRUG DELIVERY | IMMUNOGEN INC. (US) | 1996-12-17 | — | — | US | disclosed |
| US-5475092-A | Deliver cytotoxic drugs to specific cell population in targeted fashion | IMMUNOGEN INC. (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0563475-A1 | Cell binding agent conjugates of derivatives of CC-1065 | IMMUNOGEN INC (US) | 1993-10-06 | — | — | EP | disclosed |