Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 7/20 | 0.51 |
| ▸ | DHODH | Q02127 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045714 | 0.85 | RAB9A (0.47) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL9182578 | 0.85 | RAB9A (0.69) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL8057748 | 0.84 | RAB9A (0.53) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL8063415 | 0.81 | DHODH (0.51) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL8063449 | 0.81 | DHODH (0.73) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL8376590 | 0.79 | FLT1 (0.48) | CRACR2ARAB9ANPC1LMNACYP1A2 | |
| SCHEMBL9422940 | 0.75 | HTT (0.52) | CRACR2ARAB9ANPC1LMNATP53 | |
| SCHEMBL11442396 | 0.74 | RAB9A (0.66) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL8061153 | 0.73 | DHODH (0.74) | CRACR2ADHODHRAB9ANPC1GMNN | |
| SCHEMBL6707284 | 0.73 | FLT1 (0.51) | DHODHRAB9ANPC1GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646578-B1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-05-31 | — | — | EP | claimed |
| US-5506249-A | ANTIINFLAMMATORY, ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITY | ROUSSEL UCLAF (FR) | 1996-04-09 | — | — | US | claimed |
| EP-0646578-A1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-04-05 | — | — | EP | claimed |
| EP-0646578-B1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-05-31 | — | — | EP | disclosed |
| US-5506249-A | ANTIINFLAMMATORY, ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITY | ROUSSEL UCLAF (FR) | 1996-04-09 | — | — | US | disclosed |
| US-5476866-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-12-19 | — | — | US | disclosed |
| EP-0646578-A1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-04-05 | — | — | EP | disclosed |