Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | GMNN | O75496 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.67 |
| ▸ | CCKBR | P32239 | 1/20 | 0.67 |
| ▸ | MC4R | P32245 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063442 | 0.81 | DHODH (0.56) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL10425484 | 0.81 | DHODH (0.62) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL11429607 | 0.81 | DHODH (0.73) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL8045733 | 0.81 | CRACR2A (0.51) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL8061153 | 0.81 | DHODH (0.74) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL9113695 | 0.80 | DHODH (0.60) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| Leflunomide SCHEMBL5057 | 0.80 | RAB9A (1.00) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| Leflunomide SCHEMBL1243495 | 0.80 | RAB9A (1.00) | DHODHSMN1; SMN2NPC1RAB9AGMNN | |
| SCHEMBL8941902 | 0.80 | NAMPT (0.49) | DHODHSMN1; SMN2NPC1RAB9AMAOA | |
| SCHEMBL10424127 | 0.80 | DHODH (0.56) | DHODHSMN1; SMN2NPC1RAB9AGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646578-B1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-05-31 | — | — | EP | disclosed |
| US-5506249-A | ANTIINFLAMMATORY, ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITY | ROUSSEL UCLAF (FR) | 1996-04-09 | — | — | US | disclosed |
| US-5476866-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-12-19 | — | — | US | disclosed |
| EP-0646578-A1 | Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-04-05 | — | — | EP | disclosed |