Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.42 |
| ▸ | PIP4K2C | Q8TBX8 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047970 | 0.82 | HTT (0.39) | HTTPIP4K2CALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8042707 | 0.80 | ALDH1A1 (0.46) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8042763 | 0.74 | CDK1 (0.31) | LMNA | |
| SCHEMBL8045769 | 0.74 | ALDH1A1 (0.36) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8052220 | 0.74 | ALDH1A1 (0.54) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8043940 | 0.74 | ALDH1A1 (0.43) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8041800 | 0.73 | HSD17B10 (0.34) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8047415 | 0.73 | ALDH1A1 (0.34) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8045604 | 0.73 | ALDH1A1 (0.34) | HTTALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL8042600 | 0.73 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2HPGDNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |