Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046164 | 1.00 | TSHR (0.57) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL8040804 | 0.84 | CYP1A2 (0.50) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL8040803 | 0.84 | CYP1A2 (0.50) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL3681350 | 0.82 | KDM4E (0.62) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL3681348 | 0.82 | KDM4E (0.62) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL8367177 | 0.82 | KDM4E (0.62) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL7378257 | 0.79 | CA1 (0.67) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL7378259 | 0.79 | CA1 (0.67) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL13980028 | 0.78 | MAPT (0.47) | TSHRSRD5A2PTPN1 | |
| SCHEMBL4003545 | 0.77 | MAPT (0.46) | TSHRSRD5A2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0868420-B1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2000-03-29 | — | — | EP | disclosed |
| EP-0885889-A2 | Process for the preparation of pyrazole-3-carboxylic acids | SANOFI (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0868420-A1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI (FR) | 1998-10-07 | — | — | EP | disclosed |
| WO-1997021682-A1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI (FR) | 1997-06-19 | — | — | WO | disclosed |