Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | MC5R | P33032 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049971 | 0.87 | RPA1 (0.49) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8051667 | 0.85 | PDK1 (0.48) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8043083 | 0.85 | HTT (0.43) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8033921 | 0.84 | RPA1 (0.47) | RPA1SMN1; SMN2ALDH1A1HPGDUSP2 | |
| SCHEMBL8045952 | 0.84 | TSHR (0.59) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8046872 | 0.84 | RPA1 (0.52) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8052292 | 0.84 | RPA1 (0.46) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8042687 | 0.83 | RPA1 (0.48) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8044879 | 0.82 | RPA1 (0.47) | RPA1HTTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8049440 | 0.81 | RPA1 (0.51) | RPA1SMN1; SMN2ALDH1A1USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |