Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | TLR5 | O60602 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032654 | 0.85 | RPA1 (0.51) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8047508 | 0.83 | RPA1 (0.45) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8044722 | 0.83 | RPA1 (0.45) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8044879 | 0.82 | RPA1 (0.47) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8046211 | 0.81 | RPA1 (0.48) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8033943 | 0.81 | TSHR (0.61) | TSHRKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL8046872 | 0.81 | RPA1 (0.52) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8042687 | 0.81 | RPA1 (0.48) | RPA1TSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8042586 | 0.80 | RPA1 (0.47) | RPA1TSHRKDM4EHSD17B10MEN1 | |
| SCHEMBL8033921 | 0.80 | RPA1 (0.47) | RPA1TSHRKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |