Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 5/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044835 | 0.82 | USP7 (0.38) | TSHRMEN1KMT2AALDH1A1VCP | |
| SCHEMBL8045179 | 0.81 | TSHR (0.33) | TSHRMEN1KMT2AALDH1A1VCP | |
| SCHEMBL8044168 | 0.81 | MAPK8 (0.44) | MEN1KMT2AALDH1A1SIRT2 | |
| SCHEMBL8041815 | 0.79 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL8033675 | 0.78 | TSHR (0.39) | TSHRMEN1KMT2AALDH1A1VCP | |
| SCHEMBL8045350 | 0.77 | SMN1; SMN2 (0.39) | TSHRMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8042581 | 0.76 | ATM (0.47) | TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8050159 | 0.76 | LMNA (0.42) | TSHRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8050859 | 0.76 | ALDH1A1 (0.35) | TSHRMEN1KMT2AALDH1A1VCP | |
| SCHEMBL8050718 | 0.76 | HTT (0.51) | TSHRMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |