Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 2/20 | 0.37 |
| ▸ | RXRG | P48443 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046253 | 0.82 | TSHR (0.35) | RXRARXRBRXRGVCPALDH1A1 | |
| SCHEMBL8044746 | 0.82 | RXRA (0.40) | USP7RXRARXRBRXRGSMN1; SMN2 | |
| SCHEMBL8045350 | 0.81 | SMN1; SMN2 (0.39) | RXRARXRBRXRGSMN1; SMN2HTT | |
| SCHEMBL8045179 | 0.81 | TSHR (0.33) | RXRARXRBRXRGMAPK1VCP | |
| SCHEMBL8044168 | 0.80 | MAPK8 (0.44) | HTTNPSR1MAPK1ALDH1A1MEN1 | |
| SCHEMBL8052238 | 0.78 | POLB (0.45) | SMN1; SMN2HTTNPSR1HDAC6MAPK1 | |
| SCHEMBL8712945 | 0.78 | TP53 (0.51) | SMN1; SMN2CYP2C19HTTNPSR1MAPK1 | |
| SCHEMBL8034049 | 0.77 | TSHR (0.58) | SMN1; SMN2CYP2C9CYP2C19HTTNPSR1 | |
| SCHEMBL8043019 | 0.77 | HDAC6 (0.38) | RXRARXRBRXRGSMN1; SMN2CYP2C9 | |
| SCHEMBL8044772 | 0.76 | MAPT (0.38) | USP7RXRARXRBRXRGSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |