Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048729 | 0.86 | ELANE (0.47) | LMNASMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL8045225 | 0.84 | KMT2A (0.46) | LMNASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8043966 | 0.83 | MAPT (0.52) | LMNASMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL8045375 | 0.83 | NFKB1 (0.45) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8044143 | 0.82 | ALDH1A1 (0.45) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8050070 | 0.81 | NFKB1 (0.45) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8043224 | 0.81 | SMN1; SMN2 (0.44) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8041984 | 0.80 | SMN1; SMN2 (0.51) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8052342 | 0.79 | HCAR3 (0.43) | LMNANFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8033149 | 0.79 | PPARA (0.43) | LMNANFKB1NFKB2RELASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |