Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.67 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 14/20 | 0.63 |
| ▸ | MAPT | P10636 | 12/20 | 0.63 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002013 | 0.95 | L3MBTL1 (0.65) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL1998887 | 0.89 | L3MBTL1 (0.65) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL3814694 | 0.88 | ACHE (0.59) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL11326840 | 0.83 | L3MBTL4 (0.67) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL7639935 | 0.82 | TSHR (0.60) | L3MBTL4L3MBTL3L3MBTL1HPGDRAB9A | |
| SCHEMBL10107391 | 0.82 | L3MBTL1 (0.70) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL10695477 | 0.82 | ACHE (0.61) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL11890493 | 0.82 | L3MBTL4 (0.66) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL3373256 | 0.82 | L3MBTL1 (0.67) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD | |
| SCHEMBL24266488 | 0.81 | L3MBTL4 (0.65) | L3MBTL4L3MBTL3L3MBTL1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748632-B2 | Positive allosteric modulators of group II mGluRs | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | GRM2, GRM1, GRIN2C | L3MBTL4 2945/4885L3MBTL3 3149/4885L3MBTL1 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.