Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035914 | 0.92 | HDAC1 (0.41) | NPC1RAB9AHDAC1HDAC3HPGD | |
| SCHEMBL8035904 | 0.92 | NAMPT (0.46) | HPGDNAMPTOPRM1SIGMAR1TMEM97 | |
| SCHEMBL8045274 | 0.91 | HRH1 (0.40) | NPC1RAB9AHDAC1HDAC3NAMPT | |
| SCHEMBL8050645 | 0.91 | NAMPT (0.50) | HPGDNAMPTOPRM1MEN1KMT2A | |
| SCHEMBL8046961 | 0.90 | NAMPT (0.49) | HDAC1HDAC3NAMPT | |
| SCHEMBL8044991 | 0.89 | NAMPT (0.49) | HDAC3NAMPTSIGMAR1 | |
| SCHEMBL8787540 | 0.89 | HDAC3 (0.46) | HDAC1HDAC3OPRM1SIGMAR1TMEM97 | |
| SCHEMBL8053340 | 0.89 | ALDH1A1 (0.47) | HDAC1HDAC3HPGD | |
| SCHEMBL8788153 | 0.87 | NAAA (0.40) | HDAC1HDAC3MEN1KMT2AHRH1 | |
| SCHEMBL8045372 | 0.87 | ACKR3 (0.43) | NPC1RAB9AHDAC1HDAC3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |