Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.69 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.66 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048012 | 1.00 | MAOB (0.69) | MAOBTRPA1TRPM8MAOATRPM2 | |
| SCHEMBL28810074 | 0.86 | TRPM2 (0.67) | MAOBTRPA1TRPM8MAOATRPM2 | |
| SCHEMBL8047989 | 0.86 | MAOB (0.60) | MAOBTRPA1TRPM8MAOANFKB1 | |
| SCHEMBL8047998 | 0.86 | MAOB (0.60) | MAOBTRPA1TRPM8MAOANFKB1 | |
| SCHEMBL8065234 | 0.86 | GRIK1 (0.64) | MAOBTRPA1TRPM8MAOANFKB1 | |
| SCHEMBL28810071 | 0.86 | TRPM2 (0.67) | MAOBTRPA1TRPM8MAOATRPM2 | |
| SCHEMBL8065231 | 0.86 | GRIK1 (0.64) | MAOBTRPA1TRPM8MAOANFKB1 | |
| SCHEMBL8635715 | 0.84 | TRPA1 (0.78) | TRPA1TRPM8TRPM2LTB4RNFKB1 | |
| SCHEMBL8635718 | 0.84 | TRPA1 (0.78) | TRPA1TRPM8TRPM2LTB4RNFKB1 | |
| SCHEMBL2778308 | 0.82 | TRPA1 (0.71) | MAOBTRPA1TRPM8TRPM2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| EP-1003712-A1 | ANTHRANILIC ACID ANALOGS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999007669-A1 | ANTHRANILIC ACID ANALOGS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-18 | — | — | WO | disclosed |