SCHEMBL8048101

SCHEMBL8048101

Clc1cccc2sc(Sc3nnnn3-c3ccc(Br)cc3)nc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
ALDH1A1 P00352 8/20 0.40
HPGD P15428 5/20 0.40
TSHR P16473 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MAPT P10636 6/20 0.39
LMNA P02545 5/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
TP53 P04637 4/20 0.39
HSD17B10 Q99714 3/20 0.39
MAPK1 P28482 3/20 0.39
KMT2A Q03164 3/20 0.39
HTT P42858 3/20 0.39
NPSR1 Q6W5P4 2/20 0.39
PDE10A Q9Y233 1/20 0.37
EP300 Q09472 1/20 0.36
GAA P10253 3/20 0.36
KDM4E B2RXH2 1/20 0.36
MGAM O43451 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8042804 0.90 ALDH1A1 (0.49) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8044231 0.87 HSP90AA1 (0.43) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8042580 0.86 ALDH1A1 (0.51) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8042026 0.86 HSP90AA1 (0.42) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8050711 0.85 ALDH1A1 (0.41) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8032713 0.85 HPGD (0.47) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8048461 0.84 PTGS2 (0.43) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8043413 0.83 HSP90AA1 (0.41) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8050719 0.83 HSP90AA1 (0.39) HSP90AA1HSP90AB1ALDH1A1HPGDTSHR
SCHEMBL8046524 0.81 ALDH1A1 (0.58) ALDH1A1HPGDTSHRL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed