Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042804 | 0.85 | ALDH1A1 (0.49) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8033844 | 0.85 | EP300 (0.42) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8048101 | 0.84 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8042684 | 0.83 | ALDH1A1 (0.53) | PTGS2ALDH1A1NPSR1PKMLMNA | |
| SCHEMBL8032713 | 0.83 | HPGD (0.47) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8044231 | 0.82 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8042580 | 0.82 | ALDH1A1 (0.51) | HSP90AA1HSP90AB1ALDH1A1NPSR1LMNA | |
| SCHEMBL8042026 | 0.82 | HSP90AA1 (0.42) | PTGS2HSP90AA1HSP90AB1ALDH1A1NPSR1 | |
| SCHEMBL8050711 | 0.81 | ALDH1A1 (0.41) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 | |
| SCHEMBL8050719 | 0.78 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1ALDH1A1NPSR1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |