Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034063 | 0.85 | ALDH1A1 (0.36) | FBP1HSD17B10TP53JAK2TLR9 | |
| SCHEMBL8043807 | 0.80 | HSD17B10 (0.36) | FBP1HSD17B10TP53JAK2TLR9 | |
| SCHEMBL8042606 | 0.80 | ALDH1A1 (0.37) | HSD17B10TP53JAK2TLR9ALDH1A1 | |
| SCHEMBL8032781 | 0.79 | TP53 (0.46) | FBP1HSD17B10TP53JAK2TLR9 | |
| SCHEMBL8050406 | 0.79 | ALDH1A1 (0.33) | HSD17B10TP53JAK2TLR9ALDH1A1 | |
| SCHEMBL8043087 | 0.79 | ALDH1A1 (0.36) | HSD17B10TP53ALDH1A1KMT2ALMNA | |
| SCHEMBL8045604 | 0.78 | ALDH1A1 (0.34) | HSD17B10TP53ALDH1A1KMT2ALMNA | |
| SCHEMBL8045872 | 0.76 | FBP1 (0.40) | FBP1HSD17B10TP53JAK2TLR9 | |
| SCHEMBL8045496 | 0.76 | ALDH1A1 (0.33) | FBP1HSD17B10TP53JAK2TLR9 | |
| SCHEMBL8032540 | 0.76 | ALDH1A1 (0.53) | HSD17B10TP53ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |