Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 3/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034063 | 0.81 | ALDH1A1 (0.36) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8044269 | 0.81 | ALDH1A1 (0.34) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8034482 | 0.79 | ALDH1A1 (0.36) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8047415 | 0.77 | ALDH1A1 (0.34) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8043807 | 0.76 | HSD17B10 (0.36) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8048217 | 0.76 | FBP1 (0.35) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8045872 | 0.76 | FBP1 (0.40) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8046585 | 0.75 | RXRA (0.43) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8047788 | 0.75 | LMNA (0.31) | ALDH1A1TP53LMNAHTTMAPK1 | |
| SCHEMBL8032341 | 0.75 | NPC1 (0.46) | ALDH1A1LMNAHTTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |