Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042798 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4ELMNAPDE10AATM | |
| SCHEMBL8052069 | 0.80 | RAB9A (0.60) | ALDH1A1KDM4EHSD17B10EPHX2LMNA | |
| SCHEMBL8034052 | 0.78 | LMNA (0.59) | ALDH1A1KDM4EHSD17B10LMNAPDE10A | |
| SCHEMBL8043293 | 0.77 | LMNA (0.46) | ALDH1A1LMNAPDE10ARAB9AL3MBTL1 | |
| SCHEMBL8042070 | 0.76 | LMNA (0.43) | ALDH1A1KDM4ELMNAPDE10ARAB9A | |
| SCHEMBL8047450 | 0.76 | HSP90AA1 (0.44) | ALDH1A1KDM4EHSD17B10LMNAPDE10A | |
| SCHEMBL8042284 | 0.76 | TSHR (0.56) | ALDH1A1KDM4EHSD17B10LMNARAB9A | |
| SCHEMBL8032726 | 0.76 | LMNA (0.40) | ALDH1A1KDM4EHSD17B10LMNAPDE10A | |
| SCHEMBL8049958 | 0.75 | KDM4E (0.46) | ALDH1A1KDM4ELMNAPDE10AL3MBTL1 | |
| SCHEMBL8048304 | 0.74 | LMNA (0.41) | ALDH1A1KDM4ELMNAPDE10ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |