Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033095 | 0.86 | ALDH1A1 (0.52) | EP300KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL8048461 | 0.85 | PTGS2 (0.43) | EP300ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8042804 | 0.84 | ALDH1A1 (0.49) | EP300ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8045773 | 0.81 | EP300 (0.45) | EP300KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL8041878 | 0.81 | KEAP1 (0.45) | EP300KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL8032713 | 0.80 | HPGD (0.47) | EP300ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8050711 | 0.80 | ALDH1A1 (0.41) | EP300ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8048101 | 0.80 | HSP90AA1 (0.42) | EP300ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8051779 | 0.80 | ALDH1A1 (0.47) | EP300KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL8044707 | 0.79 | KEAP1 (0.43) | EP300KEAP1NFE2L2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |